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A minimum quantity of 20,000 cells per sample was collected, and the DNA histograms were further analyzed using the ModFit LT software (Verity Software House, Topsham, ME, USA) for cell cycle analysis

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208 Human PGC-1 also interacts directly with RNA and with NXF1 (Nuclear RNA export factor 1) to promote nuclear export of co-activated transcripts, essential for age-related telomere maintenance