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Time and dose selective glucose metabolism for glucose homeostasis and energy conversion in the liver

Whilst this study primarily focused on metformin-mediated effects in tumour cells, increasing evidence implicates a role for metformin in the modulation of immune cells, with metformin demonstrated to modulate macrophage polarisation (71) and the infiltration and function of T-cells (72, 73)

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The assumption that high protein from animal sources directly fuels kidney stones or worsens prediabetes overlooks the bigger picture

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