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High B12 from supplements or injections rarely causes concern

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If the solution turns cloudy, develops visible particles, or changes color at any point during the 28-day window, discard it immediately

33-35 Although single studies evaluating the efficacy of metformin for treatment of hirsutism in patients with PCOS have shown potential benefits, 36-38 meta-analyses showed no significant effects of metformin compared to placebo or oral contraceptives and decreased benefits compared to spironolactone and flutamide

doi: 10.1056/NEJMoa2108269 45 McGuireDKBusuiRPDeanfieldJInzucchiSEMannJFEMarxNet al