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Activating them lowers blood pressure and reduces inflammation and other heart-healthy changes

The Bottom Line Retatrutide is the most pharmacologically ambitious weight loss drug to reach human trials, and its 24% average body weight reduction at 48 weeks is legitimately impressive

This distinction has shown to provide substantial weight reduction and improved glycemic control in adults with obesity and type 2 diabetes

Blood pressure monitoring is also important, as these medications can lower blood pressure, potentially requiring adjustments to other medications

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