Using two GLP-1 medications simultaneously would increase the risk of serious side effects without additional benefit
When tested as a once-daily injection in single and multiple doses varying up to 0.18 mg in healthy normal to overweight volunteers, gastrointestinal adverse events (nausea, diarrhoea, constipation, vomiting) were encountered, but the drug was described as well tolerated
Hu G, Liu W, Mendelsohn J, Ellis L, Radinsky R, Andreeff M , Deisseroth AB
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As patients learn that semaglutide costs significantly less abroad, clinics may face pressure to justify pricing for name-brand or compounded GLP-1 products