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This distinction is clinically important: metformin may be prescribed for its approved indication (diabetes) in a patient with coexisting fatty liver, but prescribing it solely to treat fatty liver constitutes off-label use without robust supporting evidence

Emerging Risk Factors, C Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation

TUDCA has also been shown to have protective effects on other organs, such as the brain (thanks to its ability to cross the blood brain barrier) in which case some interesting research has shown it's potential role in treatment approaches with neurodegenerative disorders such as Alzheimer's, Parkinson's, Huntingtons and Motor Neuron Disease