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Administration of safflower and atorvastatin to hypercholesterolemic rats restored the histology of liver and heart, approaching the normal state and protecting against histological alterations ( The total body weight was gradually increased with increasing hypercholesterolemia (Tahir et al., 2023)

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Generally, a pea-sized amount for both eyes is adequate

2015 Aug;32(8):2678-2689

Myelosuppressive and hepatotoxic potential of leflunomide and methotrexate combination in a rat model of rheumatoid arthritis

This layered approach allows patients to capture both systemic and local benefits while managing cost and convenience