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Human trials have predominantly used topical or brief systemic dosing, and tolerability is overall reported to be good

Front Pharmacol 12:681417 Datta A, Kim GA, Taylor JM, Gugino SF, Farrow KN, Schumacker PT, Berkelhamer SK (2015) Mouse lung development and NOX1 induction during hyperoxia are developmentally regulated and mitochondrial ROS dependent

A randomized, triple-blind, placebo-controlled trial

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J Strength Cond Res 34(5):14801495 Gonzalez AM, Spitz RW, Ghigiarelli JJ, Sell KM, Mangine GT (2018) Acute effect of citrulline malate supplementation on upper-body resistance exercise performance in recreationally resistance-trained men