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Based on in vitro studies, CYP3A4 and CYP2D6 enzymes are responsible for dehydrogenation and hydroxylation of aripiprazole, and N-dealkylation is catalyzed by CYP3A4

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Third, GLP-1 promotes insulin gene expression and biosynthesis, which increases the expression of the transcription factor Pdx-1 and the binding of this factor to the insulin gene promoter [34]

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