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These DAMPs draw in and activate immune cells, driving ICD

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True non-response can occur when patients carry genetic variants that reduce GLP-1 or GIP receptor function, or when undiagnosed metabolic conditions such as hypothyroidism or polycystic ovary syndrome interfere with treatment efficacy

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This is the most speculative of the mechanistic arguments as applied to hair, since matrix remodeling in skin does not automatically translate to changes in the hair cycle