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But it can also be as easy as you want

10.1371/journal.pone.0027706 PLoS One 96 KitamuraK.IwanamiA.NakamuraM.YamaneJ.WatanabeK.SuzukiY.et al (2007)

As we age, chromatin tends to become heterochromatic: densely packed, transcriptionally silent, and resistant to repair [34]

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The radioactivity of the eluted solution was detected using a scintillation counter