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Urias E, Tedesco NR, Oliveri A, Raut C, Speliotes EK, Chen VL

GLP-1 acts through its receptors located on immune cells, reducing the production of inflammatory cytokines and infiltration of immune cells in the tissues

Rather than positioning medication against surgery, leading practices now view them as complementary options along a continuum of care

2019;317:E82030

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Summary of Section 10 (Mini-List) Preoperative medical therapy reduces liver size and improves operative safety GLP-1 and dual agonist medications stabilize blood sugar and metabolic function Behavioral foundations developed before surgery improve postoperative success Medical therapy can fulfill insurance prerequisites meaningfully Patients with complex medical profiles benefit from structured preoperative support What Most Patients Can Expect From Treatment Over the First Weeks and Months Early Physiologic Changes During the First Four to Twelve Weeks During the early phase of medical weight loss treatment, most patients begin noticing subtle but meaningful changes in their appetite and relationship with food