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The capability of Sp to replenish reduced glutathione levels was further tested in neuronal cells exposed to MPP + , the toxic bioactivation product of MPTP known to induce Parkinsonian phenotype in animal models 1

GLUTATHIONE BIOCHEMISTRY AND KEY PHYSICAL ROLES Background: Glutathione is a ubiquitous molecule, the major non-protein cellular thiol, found in millimolar concentrations in many cellular compartments and organelles, and is produced in all organs, especially the liver

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When both pathways are activated at the same time

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