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In recent years, numerous computational studies have investigated tyrosinase inhibitors using the structure of mushroom tyrosinase (mTYR) as a model enzyme 8,9,10,11,12

10.21037/apm.2019.01.05 12 LazicR.GabricN.DekarisI.BosnarD.Boban-BlagaicA.SikiricP

10.1152/ajplung.00456.2018 Am J Physiol Lung Cell Mol Physiol

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The perfect linker ensures adequate stability of the cytotoxic drug in the circulation, effectively prevents premature release of the drug, effectively promotes the release of the cytotoxic drug in the targeted tumor cells, and strongly promotes the efficacy and tolerability of a successful ADC

References Goodman & Gilmans The Pharmacological Basis of Therapeutics Antidotes Katzung: Basic and Clinical Pharmacology Toxicology Tripathi: Essentials of Medical Pharmacology Antidotes Harrisons Principles of Internal Medicine Drug Toxicity