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Repeated injections at one site cause lipohypertrophyfatty lumps under the skin that reduce medication absorption and create pain

Bertolini A, Ferrari A, Ottani A, Guerzoni S, Tacchi R, Leone S (2006)

range 341,529)

doi: 10.1097/MED.0b013e32834ec952 14 BrieBSarmento-CabralAPascualFCordoba-ChaconJKinemanRDBecu-VillalobosD

Key genes include GLP1R (the receptor itself), GIPR (glucose-dependent insulinotropic peptide receptor), MC4R (melanocortin pathway), and FTO (fat mass regulation)

Lahey notes more research is needed to determine the safety and efficacy of the treatments used in the study for people with both chronic health conditions