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A new paper in the Journal of Neurology, Neurosurgery & Psychiatry discusses how GLP-1RAs, drugs approved for diabetes and obesity, may play a role in the treatment of major neurocognitive disorders such as dementia

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An abundant TCA metabolite is succinate, which, like lactate, appears in the extracellular milieu, where it can be taken up by surrounding cells

Other medications, such as those that act like GLP-1, also are used to treat diabetes

One of the defining characteristics of Tesamorelin research is its interaction with the growth hormone-releasing hormone receptor (GHRHR) located on anterior pituitary somatotroph cells

Finally, a redox proteomics study of AD/mild cognitive impairment patient brains showed an increase in oxidative stress proteins (Swomley and Butterfield, 2015)