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It is not strictly unexplored, nor is it a failed target

This insulin helps your bodys cells absorb glucose, effectively lowering blood sugar levels

In this pathway, phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to produce phosphatidylcholine, utilizing S-adenosylmethionine (SAM) as a methyl donor

Haider A, Gupta KC, Kang IK

Interestingly, the magnitude of reduction decreased after 6 months, though its not clear why

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