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Chronic pain often involves nervous system sensitization, metabolic dysfunction, nutrient depletion, or low-grade inflammation that may not appear on standard imaging or routine laboratory tests

Electromyogr.Clin Neurophysiol

Frontiers in Immunology 15: 1330386

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When thyroid function is abnormalwhether overactive (hyperthyroidism) or underactive (hypothyroidism)your baseline metabolism and appetite control mechanisms already operate differently than people with normal thyroid function