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46 In headtohead comparisons with other pharmacological agents, sixmonth trials ( n = 3596) showed that 10002000 mg/day of metformin was more effective than COCPs including ethinyl estradiolcyproterone acetate (EECA) in improving asymmetric dimethylarginine, HOMAIR, homocysteine levels, blood pressure and lipid profiles, with greater reductions in Creactive protein (CRP) in women with obesity

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