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CSD has been demonstrated to activate the trigeminovascular system (TVS) both centrally and peripherally by exposing the dura to inflammatory molecules, indicating that susceptibility to CSD may contribute to the initiation of migraine attacks (26, 27)

Clinical justifications include documented intolerance to inactive ingredients, the need for a different dose, supply constraints at the local pharmacy level, or specific patient circumstances the prescriber notes in the medical record

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At this time, Novo Nordisk has not conducted studies to evaluate the effect on weight after discontinuation of Ozempic