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A consensus selection strategy was applied, retaining only compounds that exhibited reproducible binding poses and consistent interaction patterns in both receptor conformations

J Neuroinflamm (2018) 15:140

most preclinical studies use young adult animals rather than aged subjects with accumulated pathology

Tirzepatide is a medication that was originally developed for type 2 diabetes but is now also being prescribed for weight management in adults with obesity or overweight conditions

It was almost a decade after the first approval in T2D, before GLP-analogs picked up a second indication in obesity

In addition, cinchonine had a dose-dependent effect on food intake reduction compared with Vehicle (Figure 5C)