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The results of major trials are summarized in Table 1

Definition of baseline T2DM and the recurrence within a 10- or 15-year period is defined as an HbA1c level of 48 mmol/mol or higher, a blood glucose level of 6.1 mmol/L or above (plasma glucose of 7 mmol/L or above), or the use of T2DM medications (Table 2)