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Thus, whereas KEAP1 is a sulfur-utilizing sensor, NRF2 is a sulfur-regulating effector, both together comprising a sulfur-employing defense mechanism
All gene scores for each screen are provided in Extended Data Table 2
In certain embodiments, the subject may be a subject having a relatively higher baseline level of plasma and/or intracellular GSH, tGSH, or both, as compared to other children with autism
The action of estradiol is primarily directed by interaction with the estrogen receptor (ER) nuclear receptors (alpha and beta) in peripheral target tissues further modulated via feedback by GH and IGF-1 (Veldhuis et al., 2006)
As granulomas mature, they develop fibrous walls and experience a significant decrease in the number of vessels penetrating the structure, which hampers the penetration of anti-TB drugs into the necrotic and hypoxic areas of the granuloma, where M.tb persists [98, 99]
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