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While the use of substituted hydrazines in synthesis can be tedious, progress has been made through the submonomer approach, where diverse side chains can be added to a common semicarbazone intermediate, specifically the semicarbazone-protected aza-glycine
J Biol Chem (2001) 276(32):2983945
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125,139 Under chronic hyperglycemia, glycolysis becomes saturated, and excessive ROS are produced by alternative metabolic pathways to induce oxidative stress, causing mitochondrial and DNA damage
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