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The mitochondrial GSH-Px1 converts H 2 O 2 to H 2 O via oxidation of GSH to oxidized glutathione (GSSG) [101]

IPA was a more potent inhibitor of hp GSTP1-1 than IAA, with an IC 50 value of 6.5 mM

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In patients suffering from auto-immune diseases, malignant myelo-proliferative syndromes, multiple myeloma, acute and chronic lymphatic leukaemia, solid tumour, sepsis or trauma, the concentration of circulating proteasome has been found to be elevated, to correlate with the disease state, and may have prognostic significance

Good use cases include tendon irritation, ligament sprains, muscle strains, plantar fascia irritation, rotator cuff irritation, Achilles tendinopathy, patellar tendinopathy, tennis elbow, golfers elbow, and joint-adjacent soft-tissue pain