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In SPPS: Amino acids are added one at a time in the correct order

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Another UCP1-independent thermogenic mechanism involving a futile cycle in adipocytes is ER Ca 2+ cycling [11]

& Hoppe, B

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This results in a decrease in mitochondrial transcription factor TFAM and impaired mitochondrial function, which ultimately leads to increased vulnerability to oxidative stress and neuronal deterioration (Sharma A