Is dehydration really the main cause of GLP-1 headaches
Circulation 2022;145:1460-70.ArticlePubMed 93
Second, increased exposure to GLP-1RA, especially over extended durations, accentuated this protective association with a duration-response pattern
Contact your GP or NHS 111 if green stools are accompanied by severe abdominal pain, high fever, blood in stools, persistent vomiting, signs of dehydration, or jaundice
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Other research highlights: 30% of GLP-1 users tested positive for SIBO or IMO even after accounting for diabetes (5) GLP-1 medicines caused microbiome changes and altered metabolism in mice (6) GLP-1 medicines tested in humans only had noticeable microbiome changes by 48 weeks (7) Despite not necessarily having slower gut motility, one study found that 88.9% of obese patients had SIBO (8) A meta analysis of people with IBS symptoms, found that up to 78% of people had SIBO, many of whom were undiagnosed (9) Overall, Sun and colleagues (1) could not prove a mechanistic link between GLP-1 medications and SIBO, however they did find that SIBO was twice as likely in GLP-1 users
