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Nonetheless, confirmation of its efficacy across heterogeneous patient populations will require large-scale, multicenter randomized controlled trials

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Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease

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When weight loss occurs gradually, the skin's fibroblasts can continue producing collagen and elastin, allowing it to retract more effectively, but with rapid or significant weight loss, the skin's ability to contract is overwhelmed, leading to lax tissue and an inability to snap back

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