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The number of articles and potential biomarkers studied, classified by category and country, are presented in Table 1

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A canonical model for GPCR adaptation relies on receptor phosphorylation events via two possible pathways: (i) second messengerinduced kinases, namely PKA and PKC, which phosphorylate both active and inactive receptors, thus mediating a nonspecific (nonhomologous) adaptation (Fig 1A and B)

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10.1016/j.ejso.2018.12.019 156 Raghunathachar SahanaK.AkilaP.PrashantV.Sharath ChandraB.Nataraj SumaM