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For example, during Pseudomonas aeruginosa infection, butyrate modulates the maturation and effector functions of neutrophils, thereby influencing their recruitment and bactericidal capacity in the lungs and exerting complex regulation of the immune response ( Streptococcus pneumoniae pneumonia and Klebsiella pneumoniae pneumonia via nucleotide-binding oligomerization domain protein 2 (NOD2) and granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathways ( Eggerthella lenta , impairs neutrophil function

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10.1146/annurev.micro.57.030502.090938 [DOI] [PubMed] [Google Scholar] Invernizzi P, Carbone M, Jones D et al (2023) Setanaxib, a first-in-class selective NADPH oxidase 1/4 inhibitor for primary biliary cholangitis: a randomized, placebo-controlled, phase 2 trial

1995;269(4):E701E708