Lifespan extension in animal studies Rodent studies (most extensive data): Mice lifespan increased 20-42% with Epithalon Rats showed 12-25% lifespan extension Both maximum lifespan and median lifespan increased Healthspan (healthy years) improved even more Similar to effects seen with caloric restriction but without dietary limitation Study examples: Mechanisms of lifespan extension: Telomere preservation preventing cellular senescence Reduced oxidative damage to tissues Improved immune function preventing infections Better hormone regulation (pineal, reproductive) Reduced age-related diseases (cancer, cardiovascular) Human lifespan effects (theoretical): No completed human lifespan studies (require decades) If similar extension: 20% of 80-year lifespan = 16 additional years More realistically: Healthspan improvement more achievable than lifespan Quality of life in later years potentially enhanced Similar goals as other longevity interventions Limitations of animal data: Rodents humans (metabolism, telomere biology differ) Controlled lab conditions vs real-world human life Optimal dosing in humans unknown Long-term safety in humans not established Need rigorous human trials for validation Compare to other longevity approaches like growth hormone peptides at SeekPeptides
Dosing Consistency Injections offer a more controlled and consistent method of delivering NAD+
Biology and chemistry details CJC-1295 is a synthetic analog of growth-hormone-releasing hormone (GHRH)
It is the most powerful form of estrogen and is mostly produced by your ovaries
IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor
Gou and colleagues also found that HAPH was positively correlated with age, metabolic syndrome, male sex, obesity, and hypoxemia
