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In contrast, weight loss improves muscle insulin sensitivity, which, in turn, helps prevent muscle protein breakdown

Significant Weight Loss Efficacy: In a Phase II clinical trial in obese adults, high doses of retatrexate resulted in an average weight loss of up to 24.2% of initial body weight over 48 weeks

This quells inflammation, speeds the healing of skin flaps (sections of skin that are lifted up and separated from their blood supply during surgery), and boosts fat survival (in cases of fat grafting, where fat is taken from one part of the body and transferred to another)

Cutting carbohydrates alone can produce 3 to 5 pounds of water weight loss in the first week as glycogen stores deplete

Let your medical provider know about everything you take so they can look at the full picture

But he never considered trying the meds himself