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Conversion is fine for most healthy younger adults, but can be less efficient in people with MTHFR genetic variants (an estimated 25 to 40% of the population carries at least one variant), people with liver function decline (more common with age), and smokers and former smokers

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The Israel Medical Association Journal

Clinical trials using oral glucose tolerance testing demonstrated that AOD-9604 has no negative impact on carbohydrate metabolism or insulin sensitivity

However, as with many peptides, there is still a limited amount of research on the long-term effects of using AOD 9604, and much of the evidence comes from anecdotal user experiences