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3.1 Key protein targets and signaling pathways of luteolin in pulmonary fibrosis Lung fibrosis involves complex molecular interactions among cytokines, enzymes, and signaling pathways that lead to ECM accumulation, fibroblast proliferation, and inflammation

Pak J Biochem Mol Biol

Activated M1 macrophages secrete TNF- and IL-6, which downregulate GPX4 and SLC7A11 in neighboring cells, increasing ferroptosis (137)

Gastroenterology 128, A584

This can potentially reduce the risk of re-injury and help individuals return to their regular activities more quickly

While IV glutathione works faster, oral forms can still be beneficial for those seeking a gentler, long-term antioxidant boost