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Together the two catalytic sites form a pocket which has a high catalytic activity (35)

Wegovy is FDA-approved for chronic weight management in adults with obesity or overweight with a weight-related condition, and for cardiovascular risk reduction in adults with overweight or obesity and known heart disease

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A patient carrying a GLP1R variant associated with slower desensitization, for example, may experience longer symptom duration at a given dose, but this should always be interpreted alongside clinical presentation, lifestyle factors, and baseline health statusnever as a standalone predictor of treatment outcome

Wegovy has been associated with an average 15 percent loss in body weight, while Mounjaro has shown reductions of 20 percent or more