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The Shift from Diabetes to Weight Loss Medicine In the mid-2010s, researchers conducting diabetes trials noticed an unexpected pattern: patients were losing significant amounts of weight, often 1015% of their body mass

Genetic polymorphisms are heritable changes in DNA sequences as consequence of single-nucleotide polymorphisms or stable point mutations that may partially alter enzyme activity, or large deletions in coding sequences resulting in a null phenotype 24,34

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10.1016/j.cmet.2020.05.001 65 VasuP.DorairajE

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