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Jenner, Parkinson disease: from pathology to molecular disease mechanisms

Zhang XQ, Xu CF, Yu CH, Chen WX, Li YM (2014) Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease

Introduction to IGF-1 DES Development IGF-1 DES (des(1-3)IGF-1 or IGF-1 DES 1-3) represents a truncated variant of insulin-like growth factor-1 lacking the first three N-terminal amino acids

The initial model was rigid-body fitted into the consensus EM density map via UCSF Chimera 1.14 32 , followed by manual adjustment using ISOLDE 33 embedded in UCSF ChimeraX 1.6 34

3 The active molecule turned out to be a tripeptide with the sequence glycine-histidine-lysine (Gly-His-Lys), which has a strong natural affinity for copper(II) ions

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