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While DSIP functions as a broad neuromodulator within central nervous system signaling pathways, Epitalon and Orexin represent more targeted models of circadian regulation, cellular aging processes, and arousal signaling

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Key risk factors include age (over 50), vascular conditions like hypertension and diabetes, lifestyle factors such as smoking and obesity, untreated obstructive sleep apnea, and certain medications

Acknowledgements This work is supported by a grant from the National Science Foundation NSF CMMI-2027668 (to J.K.P

doi: 10.3389/fneur.2015.00252

However, this risk has not been demonstrated in humans at therapeutic doses, and the warning is being reevaluated based on post-marketing surveillance data