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TRIUMPH is Eli Lilly's Phase 3 obesity-focused retatrutide program

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The Novel DA-CH3 dual incretin restores endoplasmic reticulum stress and autophagy impairments to attenuate alzheimer-like pathology and cognitive decrements in the APPSWE/PS1E9 Mouse Model

A meta-analysis which included eight trials with a total of 60,080 patients found that GLP-1 agonists reduced major adverse cardiovascular events, all-cause mortality and hospital admissions for heart failure in treated patients with type 2 diabetes, regardless of structural homology 20

This was supported in 5xFAD mice, in which exendin-4 treatment alleviated cognitive dysfunction, prevented amyloid- accumulation, and protected mitochondrial function [54]

Resting heart-rate increase (530%): Modest average rise of a few bpm