MDPI/Brain Sciences (open access, full text): RESEARCH ADDITIONS: Dopamine tracks significance and prediction error not simply pleasure Schultz, W
They are usually just disgusting, not painful, but sometimes they can get unpleasant like a thorn in the lions paw
Will everyone who is eligible be able to get it
But it doesnt mean someone has failedor that theres nothing left to try. Doctors may adjust doses, consider other medications, revisit lifestyle supports, or discuss surgery when appropriate
During this process, PLA particles were colonized by gut microbes, forming surface biofilms and increasing pullulanase activityan enzyme that degrades branched polysaccharidesthe authors suggested this may have broken down PLA into smaller carbon-rich molecules, potentially supporting Bifidobacterium growth, without triggering pathogenic overgrowth or inflammatory responses (Jimnez-Arroyo et al., 2023)
Key takeaways for clinicians: Significant weight reduction and glycemic improvement within 7 months No psychiatric destabilization , addressing a key safety concern Could redefine metabolic management in antipsychotic-treated patients Supports integration of GLP-1 agonists into psychiatry-endocrinology collaboration models References Ganeshalingam AA, Uhrenholt N, Arnfred S, et al
