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A high urinary methylmalonic acid result helps confirm B12 deficiency

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The oral bioavailability is roughly 1%, which is why the oral doses (3 mg, 7 mg, 14 mg daily) appear higher than the injectable doses but deliver similar systemic exposure

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Evidencebased strategies to improve general medication adherence include dose simplification, patient education, electronic reminders, reduced outofpocket costs, and patient incentives [5, 276]

Atrophy of limb muscles impairs mobility, while involvement of respiratory muscles increases the risk of pulmonary infection and respiratory failure, contributing to poorer outcomes in critically ill patients