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Upon exceeding 150 CAG repeats, MSNs undergo progressive loss of neuronal characteristics while concurrently upregulating senescence-related and pro-apoptotic gene programs, culminating in neuronal degeneration

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Moreover, Cyp2e1-/- mice showed resistance to the APAP high dose-associated hepatotoxicity, whereas human CYP2E1 transgenic mice were susceptible, suggesting that CYP2E1 is the major P450 enzyme participating in APAP activation (Cheung et al., 2005)