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In recent years, the roles of oxidative stress and mitochondrial dysfunction in the progression of OA have garnered significant attention (Blanco et al., 2011

Human-grade medications are produced under strict quality control standards and are intended for use in humans, while research-grade products are made for laboratory purposes and are not tested for safety, sterility, or accurate potency

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It is also important to address a potential concern

Its supplementation is associated with improved cognitive function, enhanced muscle performance, and better metabolic health, making it popular in anti-aging and wellness therapies

Given the pronounced mitochondrial alterations under dual SHP2/MEK inhibition therapy, we focused on metabolites linked to mitochondrial and ROS metabolism