selectively overexpressed SLC7A11 in the myocardium and found that it can increase cellular GSH levels and prevent FTH deficiency-mediated iron death [76]
By contrast, controlled utilization of lactate, such as lactate post-conditioning, has been demonstrated to exert neuroprotective effects in cerebral IRI (156)
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DK thanks the Novo Nordisk Foundation for funding (grant NNF20CC0035580) and Balvi (grant 18)
In addition, functional analyses employing knockdown of MKP3, a member of the subfamily of protein tyrosine phosphatases known as dual-specificity phosphatases (MKPs) [269, 270], and ectopic overexpression revealed the role of MKP3 in negatively regulating ERK1/2 activity and inhibiting tumorigenicity and chemoresistance in vitro and in vivo