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Independent phase-variable expression has also been observed in genes involved in haemoglobin-haptoglobin acquisition (Phillips et al., 2022) which is hypothesised to provide an adaptive response to fluctuations in haem-iron availability/source influenced by the stage or site of infection (Rao et al., 1999

Many patients report increased energy within a day or two, with weight-loss benefits developing over several weeks of consistent use

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While these features are associated with a LoF phenotype, other studies suggest that both GIPR agonists and antagonists may provide benefits to T2D and obesity (Yang et al., 2022), indicating a complex mechanism of GIPR action within the processes of blood glucose and weight regulation