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Interventional studies have shown that pharmacological agents targeting metabolic and hemodynamic stress, such as SGLT2 inhibitors, GLP-1 receptor agonists, and renin-angiotensin system blockers, can partially restore plasma and urinary acylcarnitine levels

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Nutrients 13 , 4497 (2021)

That raises the question of whether and how GLP-1R agonists, which were initially developed for use in the rest of the body, make their way into the brain

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