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Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

Blocking PSAT1 pS337 with CPP elevates IFN-induced ferroptosis and enhances the efficacy of programmed cell death protein 1 (PD-1) antibodies in TNBC

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As a pharmacological agent, papaverine is not exempt from adverse effects including endothelium damage, epileptic seizures, transient neurological dysfunction, and hemodynamic changes, among others (Dipp et al., 1999)