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Despite these side effects, the risk of major cardiovascular events associated with these medications remains low [13]

Along with this metabolic profile in vitiligo patients, a lifestyle whose etiological factors are also based on low-chronic inflammation, OS, and inefficient EAS lead to the development of disorders within MetS scope and worsen vitiligos condition

These classifications are broadly accepted within the clinical and research community, with some papers defining a fourth stage of lipedema as lipolymphedema, which is the development of secondary lymphedema due to the severity of lipedema (van la Parra et al., 2023

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Other signs may include muscle aches, joint pain, and skin problems