Not as effective as tirzepatide, but dramatically more accessible
Discovery In the early 1980s, researchers discovered proglucagon, a precursor protein found in the pancreas and intestines
It has already moved into larger, late-stage trials
However, in patients treated with diclofenac and glucocorticoids, the risk of peptic ulcer and gastrointestinal bleeding may increase, so special attention should be given in case of prolonged treatment, even in the absence of serious gastrointestinal symptoms
While oral tablets and sublingual troches exist, subcutaneous injection remains the most effective delivery method
Unlike bovine insulin (which results in indefinite deferral), tirzepatide and other GLP-1 receptor agonists do not typically appear on standard medication deferral lists