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Due to its interaction with NNMT-associated pathways, 5-Amino-1MQ has become a significant area of interest in laboratory research involving metabolism, cellular energy expenditure, adipocyte biology, and nutrient utilization mechanisms

Challenges with obtaining the arterial input function to model glucose concentration in the parenchyma, its transport and utilization, the relatively long imaging time from application of multiple long TR saturation pulses, and importantly the lack of validation of CEST agents for BBB, present limitations its routine clinical use (Kogan et al., 2013

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